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Our top choices for Southwest Illinois hotels

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

1. Best Western U. S. Inn

Nashville

Steven

CA $185 total

includes taxes & fees

Nov 10 - Nov 11

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

2. Best Western Plus MidAmerica Hotel

Mascoutah

Charles

CA $162 total

includes taxes & fees

Nov 15 - Nov 16

A buffet with various food items, including omelets and other dishes, arranged on a counter with a patterned tile backsplash.

3. Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

Jo Ann

CA $138 total

includes taxes & fees

Nov 15 - Nov 16

A bar area with a long counter, multiple chairs, and hanging light fixtures.

4. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Mei

CA $177 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

5. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

CA $120 total

includes taxes & fees

Dec 1 - Dec 2

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

6. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Susan

CA $174 total

includes taxes & fees

Nov 12 - Nov 13

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

7. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

CA $116 total

includes taxes & fees

Nov 22 - Nov 23

A neatly made bed with a patterned bedspread, a framed picture above it, a chair, a lamp, and a checkered floor.

8. Powhatan Motel

Pocahontas

Bob

CA $145 total

includes taxes & fees

Nov 10 - Nov 11

A breakfast buffet with various pastries, a bowl of oranges, and a waffle batter dispenser.

9. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

CA $117 total

includes taxes & fees

Nov 15 - Nov 16

A restaurant with multiple tables and booths, large windows, and a modern interior design.

10. The Principal Hotel

Columbia

Michael

CA $147 total

includes taxes & fees

Nov 11 - Nov 12

A hotel room with a large bed, a red bedspread, a bathtub, a nightstand with a lamp, and two framed pictures on the wall.

11. Seasons Inn & Suites Highland

Highland

robert

CA $141 total

includes taxes & fees

Nov 29 - Nov 30

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

12. Best Western Plus Centralia Hotel & Suites

Centralia

Jeremy

CA $220 total

includes taxes & fees

Nov 10 - Nov 11

A hotel with a covered entrance, stone pillars, and a modern design.

13. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

CA $177 total

includes taxes & fees

Dec 10 - Dec 11

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

14. Drury Inn & Suites Marion

Marion

Heather

CA $159 total

includes taxes & fees

Nov 15 - Nov 16

A hotel lobby with a reception desk, seating area, and a large screen TV.

15. Comfort Suites Mount Vernon

Mount Vernon

Bruce and Robin

CA $187 total

includes taxes & fees

Nov 15 - Nov 16

An indoor swimming pool with a lifeguard chair, a lifebuoy, and a mural of a beach scene.

16. Super 8 by Wyndham Troy IL/St. Louis Area

Troy

Jacqueline

CA $100 total

includes taxes & fees

Dec 7 - Dec 8

A hotel room with a bed, a desk with a chair, a sofa, and a small table.

17. Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

Colleen

CA $111 total

includes taxes & fees

Nov 17 - Nov 18

A hotel room with two beds, a desk, a television, and a window with a view of the outdoors.

18. Red Bud Country Inn

Red Bud

Camille

CA $124 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bed, two bedside tables with lamps, a window with curtains, a painting on the wall, and a radiator.

19. Laketree Inn And Suites Marion

Marion

Karen

CA $118 total

includes taxes & fees

Dec 1 - Dec 2

A modern living room with a fireplace, a bookshelf, a large wall clock, and a cozy seating area.

20. Country Inn & Suites by Radisson, Marion, IL

Marion

Rhonda

CA $184 total

includes taxes & fees

Nov 16 - Nov 17

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Stay near popular Southwest Illinois attractions

O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.

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Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

See all hotels in Southwest Illinois

A tall, cylindrical structure with a red and white striped pattern and a label reading "Brock's Old Original Catsup."

Top Southwest Illinois Hotel Reviews

Motel 6 Caseyville, IL - Caseyville Il

8/10 Good

"The room was clean and had just what we needed for the night. Wish there were 4 pillows instead of 3 and more washcloths and bath towels. Didn't have time to go ask for them but we made due. Other than that for the 1 night stay we had its just what we needed."

Best Western St. Louis Fairview Heights

8/10 Good

"Much better than I expected for the price. Very quite and I had a great sleep. The room was dark and the bed was firm and comfortable. The shower head had plenty of pressure which was nice. I also was pleased with the breakfast selection. Yes, like other older hotels under new ownership, the place lacked attention to details, but for the price and location I recommend staying here."