Book The Best Hotels in Southwest Illinois, IL for 2026 from CA $80 - Fully Refundable Options

A calm lake surrounded by trees and vegetation.

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Go beyond your typical stay in Southwest Illinois

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Our top choices for Southwest Illinois hotels

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

A compact kitchenette with a refrigerator and an ice dispenser.

A Best Western U.S. Inn with a modern design, featuring a covered entrance and a parking lot.

A reception area with a stone wall, a round mirror, a reception desk, and a computer setup.

1. Best Western U. S. Inn

Nashville

Arilla

CA $155

CA $169 total

includes taxes & fees

Oct 5 - Oct 6

A bar area with a long counter, multiple chairs, and hanging light fixtures.

A spacious lobby with a reception desk, seating area, and glass doors leading outside.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a lamp.

A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.

2. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Kirstyn

CA $157

CA $177 total

includes taxes & fees

Oct 4 - Oct 5

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

A hotel room with a large bed, a desk with a chair, a sofa, and a TV.

A modern hotel room with a living area, a kitchenette, and a door leading to another room.

A spacious lobby with a stone reception desk, leather seating, and a large window offering a view of the outdoors.

3. Best Western Plus MidAmerica Hotel

Mascoutah

Danny

CA $154

CA $176 total

includes taxes & fees

Sep 27 - Sep 28

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and illuminated pillars.

An indoor swimming pool with clear lane markings, a lifeguard chair, and a window providing natural light.

A modern kitchen with a wooden cabinet, coffee maker, and storage shelves.

A hotel room with two beds, a large window, and a wall-mounted lamp.

4. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

John

CA $157

CA $177 total

includes taxes & fees

Oct 24 - Oct 25

A hotel room with a large bed, a red bedspread, a bathtub, a nightstand with a lamp, and two framed pictures on the wall.

A hotel room with a wooden dining table, four brown chairs, a beige sofa, a small wooden coffee table, a lamp, a framed picture on the wall, and a kitchenette with a microwave.

A hotel room with a sofa, two lamps, a television, and a desk.

A hotel room with a bed, a desk with a TV, a chair, a small table, and a couch.

5. Seasons Inn & Suites Highland

Highland

Jeffrey

CA $127

CA $140 total

includes taxes & fees

Oct 4 - Oct 5

A modern living room with a fireplace, blue sofa, red chairs, and a flat-screen TV mounted on a textured wall.

A hotel room with a blue armchair, a sofa, a bed, a desk, a television, and a window.

A hotel reception area with a long wooden counter, coffee machines, and a wall with framed pictures.

6. Comfort Inn & Suites Greenville I-70

Greenville

Debbie

CA $141

CA $157 total

includes taxes & fees

Oct 4 - Oct 5

A restaurant with multiple tables and booths, large windows, and a modern interior design.

A modern kitchen with a central island, bar stools, and a dining area.

A hotel named "The Principal Hotel" with a brick facade, multiple windows, and a parking lot in front.

A wooden wall with the sign "THE PRINCIPAL HOTEL" and a row of books below.

7. The Principal Hotel

Columbia

Kenny

CA $127

CA $141 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A hotel with a flat facade, multiple windows, and a sign indicating it is a 'SureStay Hotel by Best Western'.

A hallway with vending machines and a carpeted floor.

8. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

MARK

CA $114

CA $127 total

includes taxes & fees

Oct 1 - Oct 2

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

A hotel room with two beds, a nightstand, a lamp, and a framed picture on the wall.

A reception area with a desk, chairs, a red carpet, and a television mounted on the wall.

A hotel with a covered entrance, multiple rooms, and a parking lot.

9. Quality Inn Mount Vernon, IL

Mount Vernon

Matthew

CA $101

CA $115 total

includes taxes & fees

Oct 25 - Oct 26

A neatly made bed with a patterned bedspread, a framed picture above it, a chair, a lamp, and a checkered floor.

Two double beds with patterned headboards, a bedside table with a lamp, and framed pictures on the wall.

A bathroom with a sink, toilet, and a stack of towels.

10. Powhatan Motel

Pocahontas

Chris

CA $136

CA $145 total

includes taxes & fees

Sep 26 - Sep 27

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A kitchen area with a waffle maker, waffle batter dispenser, and various cooking utensils.

A hotel room with a desk, a lamp, a flat-screen TV, a telephone, a microwave, and a trash bin.

A hotel with a brick facade, a flagpole with an American flag, and a parking lot with several cars.

11. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Devin

CA $103

CA $117 total

includes taxes & fees

Sep 27 - Sep 28

An indoor swimming pool area with multiple lanes, lounge chairs, and a small seating area.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

A lobby with two armchairs, a lamp, a framed artwork, and a sign indicating a fitness center.

A lobby with patterned sofas, a fireplace, and framed pictures on the wall.

12. Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

KEVIN

CA $144

CA $167 total

includes taxes & fees

Oct 12 - Oct 13

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

An indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls. There are lounge chairs and a small seating area with tables.

A spacious lobby with a large seating area, a reception desk, and a television.

A hotel room with two beds, a large window with curtains, a wall-mounted lamp, and a patterned carpet.

13. Best Western Plus Centralia Hotel & Suites

Centralia

Corey

CA $197

CA $220 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large flat-screen TV, a desk with drawers, a bench, and a wardrobe.

A compact hotel room with a kitchenette, a blue sofa, a small wooden table, and a wooden floor.

A hot tub area with a view of the parking lot through a glass door.

A patio area with outdoor seating, including chairs and tables, and a covered area with umbrellas.

14. Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

Jeremy

CA $150

CA $166 total

includes taxes & fees

Oct 25 - Oct 26

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

A hotel room with a large bathtub, a desk with a chair, and a bed.

A modern dining area with round tables and chairs, a green booth seating area, and artwork on the walls.

A Fairfield Inn & Suites by Marriott hotel with a parking lot and a clear sky.

15. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

THERESA

CA $155

CA $175 total

includes taxes & fees

Oct 10 - Oct 11

A hotel lobby with a reception desk, seating area, and a large screen TV.

A hotel dining area with a large wooden table, red upholstered chairs, a flat-screen TV mounted above the fireplace, and a kitchen area in the background.

A brick building with a patio area featuring wicker furniture and a table.

A Comfort Suites hotel with a spacious parking lot and a modern brick facade.

16. Comfort Suites Mount Vernon

Mount Vernon

Lori

CA $166

CA $187 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a bed, bedside tables, a desk, a chair, a TV, and a window with curtains.

A covered outdoor area with a concrete walkway, large windows, and a building with a gray exterior.

A hotel lobby with a wooden reception desk, a round table, a clock, and a coat rack.

A hotel lobby with a reception desk, a clock, a chair, and a small table.

17. Budget Inn Motel

Greenville

Suzanne

CA $68

CA $76 total

includes taxes & fees

Oct 9 - Oct 10

A hotel room with a bed, a television, a desk, and a chair.

A laundry area with three washing machines and a dryer.

A reception area with a reception desk, a computer, a sewing machine, and an exit sign.

A breakfast area with a counter, microwave, coffee machine, and seating.

18. Super 8 by Wyndham Greenville

Greenville

Rebecca

CA $97

CA $107 total

includes taxes & fees

Oct 25 - Oct 26

A modern indoor pool area with a blue ceiling, large windows, and a pool with a metal ladder.

A modern hotel lobby with a seating area, a reception desk, and a 'Treats' sign in the background.

A reception desk with a "Welcome to the Prairie State" sign, a receptionist, and a digital display.

A snack and treat section with shelves stocked with various snacks, a 'Welcome to our store' sign, and a 'Treats' sign.

19. Hampton Inn O'Fallon

O'Fallon

Mary

CA $161

CA $187 total

includes taxes & fees

Oct 25 - Oct 26

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

An outdoor patio area with tables and chairs, large windows, and red umbrellas.

A hotel room with two beds, a desk, a chair, a TV, and a balcony with a view.

A modern indoor seating area with leather chairs and tables, a central round table, and a staircase leading to an upper level.

20. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Kenneth

CA $180

CA $203 total

includes taxes & fees

Oct 1 - Oct 2

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Stay near popular Southwest Illinois attractions

World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

See properties

O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.

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DuQuoin State Fairgrounds

8.2/10 (95 reviews)

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

See properties

Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

See all hotels in Southwest Illinois

A tall, modern tower with balconies, set against a clear blue sky.

Top Southwest Illinois Hotel Reviews

Drury Inn & Suites St. Louis Collinsville

10/10 Excellent

"Best bacon .."

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"Staff very professional and friendly. Food delicious."

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"Great place to stay"

Super 8 by Wyndham O'Fallon

10/10 Excellent

"Clean"

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"Breakfast"

Comfort Suites Mount Vernon

10/10 Excellent

"Very clean & updated. Great location"

Radisson Hotel Fairview Heights - St. Louis

8/10 Good

"clean pretty quiet and close to i64"

Comfort Suites Fairview Heights - St. Louis

10/10 Excellent

"Enjoyed our stay for the most part. Breakfast wasnt kept up with and stayed empty both days we stayer."

More cheap stays in Southwest Illinois

Americas Best Value Inn Collinsville St. Louis

552 Ramada Blvd Collinsville IL

CA $74

CA $85 total

Oct 11 - Oct 12

includes taxes & fees

6.4/10 (976 reviews)

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

CA $76

CA $87 total

Oct 13 - Oct 14

includes taxes & fees

6.6/10 (1,108 reviews)

Super 8 by Wyndham Collinsville St. Louis

2 Gateway Dr Collinsville IL

CA $96

CA $111 total

Sep 28 - Sep 29

includes taxes & fees

7/10 Good! (1,003 reviews)

Best Western St. Louis Fairview Heights

150 Ludwig Dr Fairview Heights IL

CA $119

CA $134 total

Oct 11 - Oct 12

includes taxes & fees

Comfort Inn Edwardsville - St. Louis

3080 S State Route 157 Edwardsville IL

CA $135

CA $155 total

Oct 18 - Oct 19

includes taxes & fees

Baymont by Wyndham Marion

2608 W Main St Marion IL

CA $136

CA $163 total

Oct 25 - Oct 26

includes taxes & fees

Hotels in Southwest Illinois with star rating

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Book Hotels in Southwest Illinois on Expedia.com

Find hotels in Southwest Illinois, IL from CA $80

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southwest Illinois

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southwest Illinois hotels

1. Best Western U. S. Inn

2. Drury Plaza Hotel Mt. Vernon

3. Best Western Plus MidAmerica Hotel

4. Holiday Inn Express & Suites Mount Vernon by IHG

5. Seasons Inn & Suites Highland

6. Comfort Inn & Suites Greenville I-70

7. The Principal Hotel

8. SureStay Hotel by Best Western Whittington Rend Lake

9. Quality Inn Mount Vernon, IL

10. Powhatan Motel

11. Super 8 by Wyndham Mt. Vernon IL

12. Drury Inn & Suites St. Louis O'Fallon, IL

13. Best Western Plus Centralia Hotel & Suites

14. Holiday Inn Express Hotel & Suites Sparta by IHG

15. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

16. Comfort Suites Mount Vernon

17. Budget Inn Motel

18. Super 8 by Wyndham Greenville

19. Hampton Inn O'Fallon

20. DoubleTree by Hilton Mt. Vernon

Stay near popular Southwest Illinois attractions

World Wide Technology Raceway

O'Fallon Family Sports Park

DuQuoin State Fairgrounds

Learn more about Southwest Illinois

Top Southwest Illinois Hotel Reviews

Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Plaza Hotel Mt. Vernon

Super 8 by Wyndham O'Fallon

Drury Inn & Suites St. Louis Fairview Heights

Comfort Suites Mount Vernon

Radisson Hotel Fairview Heights - St. Louis

Comfort Suites Fairview Heights - St. Louis

More cheap stays in Southwest Illinois

Americas Best Value Inn Collinsville St. Louis

Super 8 by Wyndham O'Fallon

Super 8 by Wyndham Collinsville St. Louis

Best Western St. Louis Fairview Heights

Comfort Inn Edwardsville - St. Louis

Baymont by Wyndham Marion

Hotels in Southwest Illinois with star rating

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